Use of electron-spin-resonance spectroscopy for studying the conformational states of peptides gramicidin S

V. T. Ivanov, A. I. Miroshnikov, L. G. Snezhkova, Yu A. Ovchinnikov, A. V. Kulikov, G. I. Likhtenshtein

Research output: Contribution to journalArticlepeer-review

Abstract

1. A new method has been proposed for studying the conformational states of peptides in solutions which is based on a consideration of the ESR spectra of their spin-labeled derivatives. 2. The synthesis of derivatives of gramicidin S containing one and two iminoxyl radicals in the2Orn and7Orn side chains has been effected. 3. On the basis of an analysis of the ESR spectra of the compounds obtained at -196°C and 30-62°C, conformations of the side chains of modified ornithine residues in chloroform and ethanol have been proposed.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalChemistry of Natural Compounds
Volume9
Issue number1
DOIs
StatePublished - 1 Jan 1973

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