Use of Intraoperative Tranexamic Acid and Wound Complications in Spine Surgery: A RetrospectiveCohort Study

Moti Kramer, Michael Drexler, Amir Herman, Tal Kalimian, Yuri Klassov, Layalee Abu Nasser

Research output: Contribution to journalArticlepeer-review


Study Design: A retrospective cohort study. Purpose: This study aims to examine the effect of tranexamic acid (TXA) on postoperative wound healing in spine surgery. Overview of Literature: TXA (Cyklokapron, Hexakapron) is a widely used anti-fibrinolytic drug that is shown to be effective in mitigating hemorrhage during and after surgery by competitively blocking plasminogen in fibrinolytic cascade. Plasminogen also plays a role in inflammatory and infectious diseases. The modulation of this role by TXA may influence the development of postoperative infectious complications. Methods: We collected and reviewed the charts of 110 patients who underwent spine surgery at our academic center. We used multivariate regression analysis to assess the factors affecting surgical site infection (SSI). Results: Of the 110 patients included in this study, 21 patients (19%) were categorized as having postoperative wound complications, 16 patients (14%) had deep or superficial wound infection, and five patients (4%) had wound dehiscence. Patients with a higher surgical invasiveness index score, longer surgeries, and older patients were found to be at risk for wound complications. TXA was determined not to be a direct risk factor for wound healing complications and SSIs. Conclusions: We found no risk of wound healing complications and SSI directly attributable to preoperative and intraoperative treatment with TXA in spine surgeries.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalAsian Spine Journal
Issue number5
StatePublished - 1 Oct 2020
Externally publishedYes


  • Fibrinolysis
  • Plasminogen
  • Spine surgery
  • Surgical invasiveness index
  • Surgical site infection
  • Surgical wound dehiscence
  • Tranexamic acid


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