Vaccinia virus infection suppresses the cell microRNA machinery

Moran Grinberg; Shlomit Gilad; Eti Meiri; Asaf Levy; Ofer Isakov; Roy Ronen; Noam Shomron; Zvi Bentwich; Yonat Shemer-Avni

doi:10.1007/s00705-012-1366-z

Vaccinia virus infection suppresses the cell microRNA machinery

Moran Grinberg, Shlomit Gilad, Eti Meiri, Asaf Levy, Ofer Isakov, Roy Ronen, Noam Shomron, Zvi Bentwich, Yonat Shemer-Avni

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host origin play an important role in controlling the virus life cycle and immunity. The aim of this study was to determine the effect of vaccinia virus (VACV) infection on the expression of host-encoded microRNAs. A marked general suppression of most microRNAs in the infected cells was observed within 24 hours after VACV infection of a number of cell types. We demonstrate that this suppression was associated with abrogation of expression of the Dicer1 enzyme, which is a key enzyme in the generation of microRNAs.

Original language	English
Pages (from-to)	1719-1727
Number of pages	9
Journal	Archives of Virology
Volume	157
Issue number	9
DOIs	https://doi.org/10.1007/s00705-012-1366-z
State	Published - 1 Sep 2012

ASJC Scopus subject areas

Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00705-012-1366-z

Cite this

@article{2965d85891474a26b51a3e1306bffff8,

title = "Vaccinia virus infection suppresses the cell microRNA machinery",

abstract = "MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host origin play an important role in controlling the virus life cycle and immunity. The aim of this study was to determine the effect of vaccinia virus (VACV) infection on the expression of host-encoded microRNAs. A marked general suppression of most microRNAs in the infected cells was observed within 24 hours after VACV infection of a number of cell types. We demonstrate that this suppression was associated with abrogation of expression of the Dicer1 enzyme, which is a key enzyme in the generation of microRNAs.",

author = "Moran Grinberg and Shlomit Gilad and Eti Meiri and Asaf Levy and Ofer Isakov and Roy Ronen and Noam Shomron and Zvi Bentwich and Yonat Shemer-Avni",

note = "Funding Information: This work was supported by the Israel Science Foundation (grant no. 1375/05) and the Israel Ministry for Science, Culture, and Sport (grant no. 3-4435). The sponsor had no role in the study.",

year = "2012",

month = sep,

day = "1",

doi = "10.1007/s00705-012-1366-z",

language = "English",

volume = "157",

pages = "1719--1727",

journal = "Archives of Virology",

issn = "0304-8608",

publisher = "Springer-Verlag Wien",

number = "9",

}

TY - JOUR

T1 - Vaccinia virus infection suppresses the cell microRNA machinery

AU - Grinberg, Moran

AU - Gilad, Shlomit

AU - Meiri, Eti

AU - Levy, Asaf

AU - Isakov, Ofer

AU - Ronen, Roy

AU - Shomron, Noam

AU - Bentwich, Zvi

AU - Shemer-Avni, Yonat

N1 - Funding Information: This work was supported by the Israel Science Foundation (grant no. 1375/05) and the Israel Ministry for Science, Culture, and Sport (grant no. 3-4435). The sponsor had no role in the study.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host origin play an important role in controlling the virus life cycle and immunity. The aim of this study was to determine the effect of vaccinia virus (VACV) infection on the expression of host-encoded microRNAs. A marked general suppression of most microRNAs in the infected cells was observed within 24 hours after VACV infection of a number of cell types. We demonstrate that this suppression was associated with abrogation of expression of the Dicer1 enzyme, which is a key enzyme in the generation of microRNAs.

AB - MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host origin play an important role in controlling the virus life cycle and immunity. The aim of this study was to determine the effect of vaccinia virus (VACV) infection on the expression of host-encoded microRNAs. A marked general suppression of most microRNAs in the infected cells was observed within 24 hours after VACV infection of a number of cell types. We demonstrate that this suppression was associated with abrogation of expression of the Dicer1 enzyme, which is a key enzyme in the generation of microRNAs.

UR - http://www.scopus.com/inward/record.url?scp=84865778138&partnerID=8YFLogxK

U2 - 10.1007/s00705-012-1366-z

DO - 10.1007/s00705-012-1366-z

M3 - Article

AN - SCOPUS:84865778138

SN - 0304-8608

VL - 157

SP - 1719

EP - 1727

JO - Archives of Virology

JF - Archives of Virology

IS - 9

ER -

Vaccinia virus infection suppresses the cell microRNA machinery

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this