TY - JOUR
T1 - Vagal nerve activity as a moderator of brain-immune relationships
AU - Ohira, Hideki
AU - Matsunaga, Masahiro
AU - Osumi, Takahiro
AU - Fukuyama, Seisuke
AU - Shinoda, Jun
AU - Yamada, Jitsuhiro
AU - Gidron, Yori
N1 - Funding Information:
This study was supported by a Health and Labor Sciences Research Grant on Research on Occupational Safety and Health from the Japan Ministry of Health, Labour, and Welfare (no. H17-RODO-5 ), and a Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area) 2010 (no. 4102-21119003 ) from the Ministry of Education, Culture, Sports, Science and Technology, Japan . The authors thank Dr. Tokiko Isowa, Ms. Naho Ichikawa, Dr. Kenta Kimura, Dr. Makoto Miyakoshi, Dr. Noriaki Kanayama, and Dr. Hiroki Murakami for technical supports.
PY - 2013/5/15
Y1 - 2013/5/15
N2 - We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity.
AB - We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity.
KW - Heart rate variability
KW - Natural killer cells
KW - Neuroimmunomodulation
KW - Positron emission tomography
KW - Vagus nerve
UR - https://www.scopus.com/pages/publications/84878630145
U2 - 10.1016/j.jneuroim.2013.04.011
DO - 10.1016/j.jneuroim.2013.04.011
M3 - Article
C2 - 23684123
AN - SCOPUS:84878630145
SN - 0165-5728
VL - 260
SP - 28
EP - 36
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -