Variations in the human olfactory receptor pathway

I. Menashe, D. Lancet

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Of all five senses, olfaction is the most complex molecular mechanism, as it comprises hundreds of receptor proteins enabling it to detect and discriminate thousands of odorants. Until lately, the understanding of this highly sophisticated sensory neuronal pathway has been rather sketchy. The sequencing of the human genome and the consequent advent of new genomic tools have opened new opportunities to better understand this multifaceted biological system. Here, we present the relevant progresses made in the last decade and highlight the possible genetic mechanisms of human olfactory variability.

Original languageEnglish GB
Pages (from-to)1485-1493
Number of pages9
JournalCellular and Molecular Life Sciences
Volume63
Issue number13
DOIs
StatePublished - 1 Jul 2006
Externally publishedYes

Keywords

  • Congenital general anosmia
  • Olfactory receptors
  • Pseudogenes
  • SNPs
  • Specific anosmia
  • Threshold sensitivity

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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