Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice

Fouad Khalil, Rabea Asleh, Radha Kanneganti Perue, Jean Marc Weinstein, Adam Solomon, Batya Betesh-Abay, Alexandros Briasoulis, Hilmi Alnsasra

    Research output: Contribution to journalReview articlepeer-review

    3 Scopus citations

    Abstract

    Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions.

    Original languageEnglish
    Article number757
    JournalBiomedicines
    Volume11
    Issue number3
    DOIs
    StatePublished - 1 Mar 2023

    Keywords

    • continuous flow left ventricular assist device
    • coronary artery disease
    • gastrointestinal bleeding
    • peripheral artery disease
    • pulmonary hypertension
    • stroke

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology
    • Medicine (miscellaneous)

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