Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice

Fouad Khalil; Rabea Asleh; Radha Kanneganti Perue; Jean Marc Weinstein; Adam Solomon; Batya Betesh-Abay; Alexandros Briasoulis; Hilmi Alnsasra

doi:10.3390/biomedicines11030757

Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice

Fouad Khalil, Rabea Asleh, Radha Kanneganti Perue, Jean Marc Weinstein, Adam Solomon, Batya Betesh-Abay, Alexandros Briasoulis, Hilmi Alnsasra

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions.

Original language	English
Article number	757
Journal	Biomedicines
Volume	11
Issue number	3
DOIs	https://doi.org/10.3390/biomedicines11030757
State	Published - 1 Mar 2023

Keywords

continuous flow left ventricular assist device
coronary artery disease
gastrointestinal bleeding
peripheral artery disease
pulmonary hypertension
stroke

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/biomedicines11030757

Cite this

@article{879a409547db4f6b8f359dc12b155258,

title = "Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice",

abstract = "Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions.",

keywords = "continuous flow left ventricular assist device, coronary artery disease, gastrointestinal bleeding, peripheral artery disease, pulmonary hypertension, stroke",

author = "Fouad Khalil and Rabea Asleh and Perue, {Radha Kanneganti} and Weinstein, {Jean Marc} and Adam Solomon and Batya Betesh-Abay and Alexandros Briasoulis and Hilmi Alnsasra",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

day = "1",

doi = "10.3390/biomedicines11030757",

language = "English",

volume = "11",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - Vascular Function in Continuous Flow LVADs

T2 - Implications for Clinical Practice

AU - Khalil, Fouad

AU - Asleh, Rabea

AU - Perue, Radha Kanneganti

AU - Weinstein, Jean Marc

AU - Solomon, Adam

AU - Betesh-Abay, Batya

AU - Briasoulis, Alexandros

AU - Alnsasra, Hilmi

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions.

AB - Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions.

KW - continuous flow left ventricular assist device

KW - coronary artery disease

KW - gastrointestinal bleeding

KW - peripheral artery disease

KW - pulmonary hypertension

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85151519440&partnerID=8YFLogxK

U2 - 10.3390/biomedicines11030757

DO - 10.3390/biomedicines11030757

M3 - Review article

C2 - 36979735

AN - SCOPUS:85151519440

SN - 2227-9059

VL - 11

JO - Biomedicines

JF - Biomedicines

IS - 3

M1 - 757

ER -

Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this