TY - JOUR
T1 - Vasopressin effect on learning in 6-hydroxydopamine-pretreated rats
T2 - Correlation with caudate vasopressin levels
AU - Hamburger-Bar, R.
AU - Ebstein, R. P.
AU - Belmaker, R. H.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Conditioned avoidance learning was studied at 2 months of age in rats treated with intracisternal 6-OH dopamine (DA) at 5 days of life after desipramine pretreatment. Subcutaneous DDAVP 20 μg/rat or LVP 1 μg/rat improved conditioned avoidance learning in the 6-OH DA-treated rats at least as much as in control rats. Caudate vasopressin levels significantly correlated with learning ability in the shuttle box in control rats (r = 0.69, n = 8), 6-OH DA-treated rats (r = 0.64, n = 8), 6-OH DA plus DDAVP-treated rats (r = 0.60, n = 9), or in the total sample (r = 0.59, n = 25, p < 0.01).
AB - Conditioned avoidance learning was studied at 2 months of age in rats treated with intracisternal 6-OH dopamine (DA) at 5 days of life after desipramine pretreatment. Subcutaneous DDAVP 20 μg/rat or LVP 1 μg/rat improved conditioned avoidance learning in the 6-OH DA-treated rats at least as much as in control rats. Caudate vasopressin levels significantly correlated with learning ability in the shuttle box in control rats (r = 0.69, n = 8), 6-OH DA-treated rats (r = 0.64, n = 8), 6-OH DA plus DDAVP-treated rats (r = 0.60, n = 9), or in the total sample (r = 0.59, n = 25, p < 0.01).
UR - http://www.scopus.com/inward/record.url?scp=0021271860&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0021271860
VL - 19
SP - 735
EP - 743
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 5
ER -