Vasopressin effect on learning in 6-hydroxydopamine-pretreated rats: Correlation with caudate vasopressin levels

R. Hamburger-Bar, R. P. Ebstein, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Conditioned avoidance learning was studied at 2 months of age in rats treated with intracisternal 6-OH dopamine (DA) at 5 days of life after desipramine pretreatment. Subcutaneous DDAVP 20 μg/rat or LVP 1 μg/rat improved conditioned avoidance learning in the 6-OH DA-treated rats at least as much as in control rats. Caudate vasopressin levels significantly correlated with learning ability in the shuttle box in control rats (r = 0.69, n = 8), 6-OH DA-treated rats (r = 0.64, n = 8), 6-OH DA plus DDAVP-treated rats (r = 0.60, n = 9), or in the total sample (r = 0.59, n = 25, p < 0.01).

Original languageEnglish
Pages (from-to)735-743
Number of pages9
JournalBiological Psychiatry
Volume19
Issue number5
StatePublished - 1 Jan 1984
Externally publishedYes

Fingerprint

Dive into the research topics of 'Vasopressin effect on learning in 6-hydroxydopamine-pretreated rats: Correlation with caudate vasopressin levels'. Together they form a unique fingerprint.

Cite this