Abstract
Conditioned avoidance learning was studied at 2 months of age in rats treated with intracisternal 6-OH dopamine (DA) at 5 days of life after desipramine pretreatment. Subcutaneous DDAVP 20 μg/rat or LVP 1 μg/rat improved conditioned avoidance learning in the 6-OH DA-treated rats at least as much as in control rats. Caudate vasopressin levels significantly correlated with learning ability in the shuttle box in control rats (r = 0.69, n = 8), 6-OH DA-treated rats (r = 0.64, n = 8), 6-OH DA plus DDAVP-treated rats (r = 0.60, n = 9), or in the total sample (r = 0.59, n = 25, p < 0.01).
| Original language | English |
|---|---|
| Pages (from-to) | 735-743 |
| Number of pages | 9 |
| Journal | Biological Psychiatry |
| Volume | 19 |
| Issue number | 5 |
| State | Published - 1 Jan 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biological Psychiatry