Ventriculitis caused by Klebsiella pneumoniae successfully treated with pefloxacin in a neonate

Nehama Linder, J. Kuint, B. Reichman, N. Keler, G. Keren, R. Dagan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Pefloxacin was applied to a newborn suffering from ventriculitis caused by Klebsiella pneumoniae after failure of routine antibiotics. Treatment was successful. Blood and CSF levels were high, thus documenting good CSF penetration. In addition to this case report, a review of the literature regarding seven neonates with CNS infection treated with fluoroquinolones and from whom CSF levels were obtained, is presented. In conclusion, due to their excellent activity against gram-negative microorganisms, fluoroquinolones may be considered in the treatment of neonatal CNS infections if the pathogen is resistant to routinely used antibiotics. Only limited experience is available with fluoroquinolones in pediatric patients given their potential for cartilage toxicity in young animals.

Original languageEnglish
Pages (from-to)210-212
Number of pages3
JournalInfection
Volume22
Issue number3
DOIs
StatePublished - 1 May 1994
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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