Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops

Tim Westland, Eliza K. Patryn, Carla P. Nieuwendaal, Ivanka J.E. van der Meulen, Maarten P. Mourits, Ruth Lapid-Gortzak

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. Methods: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. Results: Quick resolution of the shield ulcers and complete re-epithelialization within 14–25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. Conclusions: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalInternational Ophthalmology
Issue number1
StatePublished - 1 Feb 2018
Externally publishedYes


  • Allergy
  • Cyclosporine A
  • Immunomodulation
  • Shield ulcer
  • Vernal catarrh
  • Vernal keratoconjunctivitis

ASJC Scopus subject areas

  • Ophthalmology


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