Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops

Tim Westland; Eliza K. Patryn; Carla P. Nieuwendaal; Ivanka J.E. van der Meulen; Maarten P. Mourits; Ruth Lapid-Gortzak

doi:10.1007/s10792-016-0424-z

Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops

Tim Westland, Eliza K. Patryn, Carla P. Nieuwendaal, Ivanka J.E. van der Meulen, Maarten P. Mourits, Ruth Lapid-Gortzak

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. Methods: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. Results: Quick resolution of the shield ulcers and complete re-epithelialization within 14–25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. Conclusions: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.

Original language	English
Pages (from-to)	363-368
Number of pages	6
Journal	International Ophthalmology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s10792-016-0424-z
State	Published - 1 Feb 2018
Externally published	Yes

Keywords

Allergy
Cyclosporine A
Immunomodulation
Shield ulcer
Vernal catarrh
Vernal keratoconjunctivitis

ASJC Scopus subject areas

Ophthalmology

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10.1007/s10792-016-0424-z

Cite this

@article{453da4b30762401893198e94a158c01e,

title = "Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops",

abstract = "Purpose: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. Methods: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. Results: Quick resolution of the shield ulcers and complete re-epithelialization within 14–25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. Conclusions: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.",

keywords = "Allergy, Cyclosporine A, Immunomodulation, Shield ulcer, Vernal catarrh, Vernal keratoconjunctivitis",

author = "Tim Westland and Patryn, {Eliza K.} and Nieuwendaal, {Carla P.} and {van der Meulen}, {Ivanka J.E.} and Mourits, {Maarten P.} and Ruth Lapid-Gortzak",

note = "Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media Dordrecht.",

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doi = "10.1007/s10792-016-0424-z",

language = "English",

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T1 - Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops

AU - Westland, Tim

AU - Patryn, Eliza K.

AU - Nieuwendaal, Carla P.

AU - van der Meulen, Ivanka J.E.

AU - Mourits, Maarten P.

AU - Lapid-Gortzak, Ruth

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. Methods: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. Results: Quick resolution of the shield ulcers and complete re-epithelialization within 14–25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. Conclusions: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.

AB - Purpose: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. Methods: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. Results: Quick resolution of the shield ulcers and complete re-epithelialization within 14–25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. Conclusions: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.

KW - Allergy

KW - Cyclosporine A

KW - Immunomodulation

KW - Shield ulcer

KW - Vernal catarrh

KW - Vernal keratoconjunctivitis

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U2 - 10.1007/s10792-016-0424-z

DO - 10.1007/s10792-016-0424-z

M3 - Article

C2 - 28120172

AN - SCOPUS:85010764982

SN - 0165-5701

VL - 38

SP - 363

EP - 368

JO - International Ophthalmology

JF - International Ophthalmology

IS - 1

ER -

Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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