TY - JOUR
T1 - Vertebrae but not femur marrow fat transiently decreases in response to body weight loss in an 18-month randomized control trial
AU - Ofir, Noa
AU - Mizrakli, Yuval
AU - Greenshpan, Yariv
AU - Gepner, Yftach
AU - Sharabi, Omri
AU - Tsaban, Gal
AU - Zelicha, Hila
AU - Yaskolka Meir, Anat
AU - Ceglarek, Uta
AU - Stumvoll, Michael
AU - Blüher, Matthias
AU - Chassidim, Yoash
AU - Rudich, Assaf
AU - Reiner-Benaim, Anat
AU - Shai, Iris
AU - Shelef, Ilan
AU - Gazit, Roi
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/6/1
Y1 - 2023/6/1
N2 - Background: Increased levels of bone marrow adipose tissue (BMAT) are negatively associated with skeletal health and hematopoiesis. BMAT is known to increase with age; however, the effect of long-term weight loss on BMAT is still unknown. Objective: In this study, we examined BMAT response to lifestyle-induced weight loss in 138 participants (mean age 48 y; mean body mass index 31 kg/m2), who participated in the CENTRAL-MRI trial. Methods: Participants were randomized for dietary intervention of low-fat or low-carb, with or without physical activity. Magnetic resonance imaging (MRI) was used to quantify BMAT and other fat depots at baseline, six and eighteen months of intervention. Blood biomarkers were also measured at the same time points. Results: At baseline, the L3 vertebrae BMAT is positively associated with age, HDL cholesterol, HbA1c and adiponectin; but not with other fat depots or other metabolic markers tested. Following six months of dietary intervention, the L3 BMAT declined by an average of 3.1 %, followed by a return to baseline after eighteen months (p < 0.001 and p = 0.189 compared to baseline, respectively). The decrease of BMAT during the first six months was associated with a decrease in waist circumference, cholesterol, proximal-femur BMAT, and superficial subcutaneous adipose tissue (SAT), as well as with younger age. Nevertheless, BMAT changes did not correlate with changes in other fat depots. Conclusions: We conclude that physiological weight loss can transiently reduce BMAT in adults, and this effect is more prominent in younger adults. Our findings suggest that BMAT storage and dynamics are largely independent of other fat depots or cardio-metabolic risk markers, highlighting its unique functions.
AB - Background: Increased levels of bone marrow adipose tissue (BMAT) are negatively associated with skeletal health and hematopoiesis. BMAT is known to increase with age; however, the effect of long-term weight loss on BMAT is still unknown. Objective: In this study, we examined BMAT response to lifestyle-induced weight loss in 138 participants (mean age 48 y; mean body mass index 31 kg/m2), who participated in the CENTRAL-MRI trial. Methods: Participants were randomized for dietary intervention of low-fat or low-carb, with or without physical activity. Magnetic resonance imaging (MRI) was used to quantify BMAT and other fat depots at baseline, six and eighteen months of intervention. Blood biomarkers were also measured at the same time points. Results: At baseline, the L3 vertebrae BMAT is positively associated with age, HDL cholesterol, HbA1c and adiponectin; but not with other fat depots or other metabolic markers tested. Following six months of dietary intervention, the L3 BMAT declined by an average of 3.1 %, followed by a return to baseline after eighteen months (p < 0.001 and p = 0.189 compared to baseline, respectively). The decrease of BMAT during the first six months was associated with a decrease in waist circumference, cholesterol, proximal-femur BMAT, and superficial subcutaneous adipose tissue (SAT), as well as with younger age. Nevertheless, BMAT changes did not correlate with changes in other fat depots. Conclusions: We conclude that physiological weight loss can transiently reduce BMAT in adults, and this effect is more prominent in younger adults. Our findings suggest that BMAT storage and dynamics are largely independent of other fat depots or cardio-metabolic risk markers, highlighting its unique functions.
KW - Body composition
KW - Bone marrow adipose tissue
KW - Bone marrow physiology
KW - Lifestyle weight-loss strategies
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=85149822398&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2023.116727
DO - 10.1016/j.bone.2023.116727
M3 - Article
C2 - 36898571
AN - SCOPUS:85149822398
SN - 8756-3282
VL - 171
JO - Bone
JF - Bone
M1 - 116727
ER -