Very low sperm count affects the result of intracytoplasmic sperm injection

D. Strassburger, S. Friedler, A. Raziel, M. Schachter, E. Kasterstein, R. Ron-El

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Purpose: The aim was to examine the influence of extremely low sperm count on intracytoplasmic sperm injection (ICSI) outcome. Methods: Over 1000 consecutive unselected ICSI cycles were divided into four groups according to sperm concentration of their patients: A, cryptozoospermia, 107 patients; B, sperm concentration of ≤ 1 x 104, 146 patients; C, sperm count of 1 x 104-1 x 105, 135 patients; and concentration of > 1 x 105 and < 10 x 106/ml (control group), 688 patients. Results: A significant decrease in pregnancy rate was noticed in the cryptozoospermic group in comparison to the control group (20% vs. 31%). Fertilization rate in group A was significantly lower in comparison to all other groups, respectively (46% vs. 52%, 54%, 61%). Embryo quality was inferior in group A in comparison to the control group. A higher yet not statistically significant abortion rate was observed in the cryptozoospermic group (as well as in group C) (30%, 27%) compared to the control group (15%). Conclusions: It seems that an extremely low sperm count has a negative effect on the outcome of ICSI. Nevertheless patients with cryptozoospermia should not be offered ICSI treatment with the ejaculated sperm before karyotype is established.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Issue number8
StatePublished - 8 Nov 2000
Externally publishedYes


  • Cryptozoospermia
  • Fertilization rate
  • Intracytoplasmic sperm injection
  • Sperm count

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)


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