Abstract
The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.
Original language | English |
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Pages (from-to) | 659-665 |
Number of pages | 7 |
Journal | ACS Chemical Biology |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - 20 Apr 2012 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine