Vibrio cholerae autoinducer CAI-1 interferes with pseudomonas aeruginosa quorum sensing and inhibits its growth

Hadas Ganin, Yael Danin-Poleg, Yechezkel Kashi, Michael M. Meijler

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.

Original languageEnglish
Pages (from-to)659-665
Number of pages7
JournalACS Chemical Biology
Volume7
Issue number4
DOIs
StatePublished - 20 Apr 2012

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