This is the protocol for a review and there is no abstract. The objectives are as follows: To evaluate the effectiveness of virtual reality (VR) exercise interventions for rehabilitation in patients with Parkinson's disease (PD). VR exercise interventions will be compared with usual care, a placebo control intervention, or any other exercise intervention without VR. Our primary objective is to determine the effect of VR exercise interventions on gait and balance in patients with PD. Our secondary objectives are to determine the effects of VR exercise interventions on (1) global motor function, (2) cognitive function, (3) activities of daily living, (4) quality of life, (5) number and types of adverse events, and (6) therapy adherence in patients with PD.