TY - JOUR
T1 - Virulence of Streptococcus pneumoniae may be determined independently of capsular polysaccharide
AU - Mizrachi Nebenzahl, Y.
AU - Porat, N.
AU - Lifshitz, S.
AU - Novick, S.
AU - Levi, A.
AU - Ling, E.
AU - Liron, O.
AU - Mordechai, S.
AU - Sahu, R. K.
AU - Dagan, R.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Mice were inoculated intranasally with Streptococcus pneumoniae isolates of serotype 14 with different genetic backgrounds (14R, 14DW) and a capsular switch of 14R, strain 9VR (serotype 9V). Inoculation of the mice with 14R and 9VR resulted in 60% mortality. All the mice survived 14DW inoculation. No differences in lungs' bacterial loads were found 3 h following inoculation. Bacterial clearance of 5 logs was observed 48 h after inoculation with 14DW versus within 1 log 48 h after inoculation with 14R and 9VR. No significant differences in bacterial size or the capsular amount could be found between 14R and 14DW. We conclude that factor(s) in addition to the capsule, contribute to disease outcome.
AB - Mice were inoculated intranasally with Streptococcus pneumoniae isolates of serotype 14 with different genetic backgrounds (14R, 14DW) and a capsular switch of 14R, strain 9VR (serotype 9V). Inoculation of the mice with 14R and 9VR resulted in 60% mortality. All the mice survived 14DW inoculation. No differences in lungs' bacterial loads were found 3 h following inoculation. Bacterial clearance of 5 logs was observed 48 h after inoculation with 14DW versus within 1 log 48 h after inoculation with 14R and 9VR. No significant differences in bacterial size or the capsular amount could be found between 14R and 14DW. We conclude that factor(s) in addition to the capsule, contribute to disease outcome.
KW - Capsular polysaccharide
KW - Microbial pathogenesis
KW - Streptococcus pneumoniae
KW - Virulence factors
UR - http://www.scopus.com/inward/record.url?scp=12144286338&partnerID=8YFLogxK
U2 - 10.1016/j.femsle.2004.02.003
DO - 10.1016/j.femsle.2004.02.003
M3 - Article
C2 - 15043881
AN - SCOPUS:12144286338
SN - 0378-1097
VL - 233
SP - 147
EP - 152
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 1
ER -
