Visceral Adipose Tissue E2F1-miRNA206/210 Pathway Associates with Type 2 Diabetes in Humans with Extreme Obesity

Nitzan Maixner, Yulia Haim, Matthias Blüher, Vered Chalifa-Caspi, Isana Veksler-Lublinsky, Nataly Makarenkov, Uri Yoel, Nava Bashan, Idit F. Liberty, Ivan Kukeev, Oleg Dukhno, Dan Levy, Assaf Rudich

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: Up-regulated expression of transcription-factor E2F1 in human visceral adipose tissue (VAT) characterizes a dysmetabolic obesity sub-phenotype. An E2F1-miRNA network has been described in multiple cancers. Here we investigated whether elevated VAT-E2F1 in obesity is associated with VAT-miRNA alterations similar to, or distinct from, those described in cancer. Furthermore, we assessed if E2F1-associated miRNA changes may contribute to the link between high- VAT-E2F1 and a dysmetabolic obesity phenotype. Methods: We assembled a cohort of patients with obesity and high-VAT-E2F1, matched by age, sex, ±BMI to patients with low-VAT-E2F1, with and without obesity (8 patients/groupX3 groups).

Original languageEnglish
Article number3046
JournalCells
Volume11
Issue number19
DOIs
StatePublished - 1 Oct 2022

Keywords

  • E2F1
  • dys-glycemia
  • miR-206
  • miR-210-5p
  • obesity

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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