Abstract
Objective: Up-regulated expression of transcription-factor E2F1 in human visceral adipose tissue (VAT) characterizes a dysmetabolic obesity sub-phenotype. An E2F1-miRNA network has been described in multiple cancers. Here we investigated whether elevated VAT-E2F1 in obesity is associated with VAT-miRNA alterations similar to, or distinct from, those described in cancer. Furthermore, we assessed if E2F1-associated miRNA changes may contribute to the link between high- VAT-E2F1 and a dysmetabolic obesity phenotype. Methods: We assembled a cohort of patients with obesity and high-VAT-E2F1, matched by age, sex, ±BMI to patients with low-VAT-E2F1, with and without obesity (8 patients/groupX3 groups).
Original language | English |
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Article number | 3046 |
Journal | Cells |
Volume | 11 |
Issue number | 19 |
DOIs | |
State | Published - 1 Oct 2022 |
Keywords
- E2F1
- dys-glycemia
- miR-206
- miR-210-5p
- obesity
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology