The possible antagonistic interaction of vitamin A and corticosteroids in wound healing was studied in several groups of rats. Follow-up showed that hydrocortisone did not delay wound healing, whereas a long-acting preparation of 6α-methylprednisolone (Depo-Medrol®) suppressed spontaneous healing of open wounds. Topical application of vitamin A caused a further delay in healing, whereas systemic use of vitamin A had no consistent effect. Since no beneficial effect of vitamin A could be demonstrated, and in view of its possible toxicity, we recommend that the clinical use of vitamin A in wound treatment be reconsidered.
|Number of pages||4|
|Journal||Israel Journal of Medical Sciences|
|State||Published - 1 Jan 1980|
ASJC Scopus subject areas