Vitamin A and corticosteroid interaction in wound healing in rats

J. Golan, S. Mitelman, A. Baruchin, N. Ben-Hur

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The possible antagonistic interaction of vitamin A and corticosteroids in wound healing was studied in several groups of rats. Follow-up showed that hydrocortisone did not delay wound healing, whereas a long-acting preparation of 6α-methylprednisolone (Depo-Medrol®) suppressed spontaneous healing of open wounds. Topical application of vitamin A caused a further delay in healing, whereas systemic use of vitamin A had no consistent effect. Since no beneficial effect of vitamin A could be demonstrated, and in view of its possible toxicity, we recommend that the clinical use of vitamin A in wound treatment be reconsidered.

Original languageEnglish
Pages (from-to)572-575
Number of pages4
JournalIsrael Journal of Medical Sciences
Issue number8
StatePublished - 1 Jan 1980
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering


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