Abstract
The possible antagonistic interaction of vitamin A and corticosteroids in wound healing was studied in several groups of rats. Follow-up showed that hydrocortisone did not delay wound healing, whereas a long-acting preparation of 6α-methylprednisolone (Depo-Medrol®) suppressed spontaneous healing of open wounds. Topical application of vitamin A caused a further delay in healing, whereas systemic use of vitamin A had no consistent effect. Since no beneficial effect of vitamin A could be demonstrated, and in view of its possible toxicity, we recommend that the clinical use of vitamin A in wound treatment be reconsidered.
| Original language | English |
|---|---|
| Pages (from-to) | 572-575 |
| Number of pages | 4 |
| Journal | Israel Journal of Medical Sciences |
| Volume | 16 |
| Issue number | 8 |
| State | Published - 1 Jan 1980 |
| Externally published | Yes |
ASJC Scopus subject areas
- Bioengineering