Vitamin a supplementation and childhood morbidity from diarrhea and respiratory infections: A meta-analysis

Itamar Grotto, Marc Mimouni, Michael Gdalevich, Daniel Mimouni

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Objectives. To perform an updated meta-analysis of the effect of vitamin A supplementation on childhood morbidity from respiratory tract infections and diarrhea. Study design. A comprehensive search of the 1966 to 2000 MEDLINE database and review of the reference lists of relevant articles identified 9 randomized controlled trials dealing with morbidity from respiratory infections and diarrhea in children 6 months to 7 years of age and provided "intention-to-treat" data. Results. The combined results indicated that vitamin A supplementation has no consistent overall protective effect on the incidence of diarrhea (relative risk, 1.00; 95% CI, 0.94-1.07) and that it slightly increases the incidence of respiratory tract infections (relative risk, 1.08; 95% CI, 1.05-1.11). Conclusions. High-dose vitamin A supplements are not recommended on a routine basis for all preschool children and should be offered only to individuals or populations with vitamin A deficiency.

Original languageEnglish
Pages (from-to)297-304
Number of pages8
JournalJournal of Pediatrics
Volume142
Issue number3
DOIs
StatePublished - 1 Mar 2003

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