Vitamin B12 could be a "Master Key" in the regulation of multiple pathological processes

Ilia Volkov, Yan Press, Inna Rudoy

    Research output: Contribution to journalReview articlepeer-review

    27 Scopus citations


    Multifunctional systems must maintain homeostasis. Man is an ideal example of a system that constantly aspires to attain optimal regulation, even under the stress of severe disease. We assume that there are universal, interchangeable (as required) biologically active substances that regulate the system and try to keep it in balance. We propose that one of these substances is vitamin B12. Why vitamin B12? The list of organs and body systems in which vitamin B12 plays a functional role is constantly being added to. Vitamin B12 affects the normal growth of children, the peripheral and central nervous systems, bone marrow, skin, mucous membranes, bones, and vessels. It is possible that even when the serum cobalamin level is normal, treatment with vitamin B12 could correct defects caused by other biologically active substances. We call this phenomenon the "Master Key" effect. We suggest that this "Master Key" concept can be tested by treating diseases, such as recurrent stomatitis, various forms of hyperpigmentation, trophic ulcers, and burns, with vitamin B12, even if the B12 serum level is normal.

    Original languageEnglish
    Pages (from-to)65-69
    Number of pages5
    JournalJournal of Nippon Medical School
    Issue number2
    StatePublished - 4 May 2006


    • Cobalamin
    • Vitamin B12
    • Vitamin B12 supplementation

    ASJC Scopus subject areas

    • General Medicine


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