TY - JOUR
T1 - Vitamin C for the treatment of recurrent furunculosis in patients with impaired neutrophil functions
AU - Levy, R.
AU - Shriker, O.
AU - Porath, A.
AU - Riesenberg, K.
AU - Schlaeffer, F.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - The effect of vitamin C treatment on 23 patients with a history of recurrent furunculosis with negative nasal cultures was studied. Neutrophil functions (chemotaxis, phagocytosis, or superoxide generation) of 12 patients were significantly lower than those of the matched controls. In this group, treatment with vitamin C (1 g/day) caused a dramatic clinical response as well as a significant improvement of neutrophil functions, reaching values similar to those of the controls. Two patients remained vitamin C-dependent. In the patients with normal neutrophil functions, vitamin C treatment neither affected neutrophil activity nor caused a clinical response. Therefore, patients suffering from recurrent furunculosis with defective neutrophil functions may be treated successfully with vitamin C, contributing to both neutrophil function recovery and a dramatic clinical response.
AB - The effect of vitamin C treatment on 23 patients with a history of recurrent furunculosis with negative nasal cultures was studied. Neutrophil functions (chemotaxis, phagocytosis, or superoxide generation) of 12 patients were significantly lower than those of the matched controls. In this group, treatment with vitamin C (1 g/day) caused a dramatic clinical response as well as a significant improvement of neutrophil functions, reaching values similar to those of the controls. Two patients remained vitamin C-dependent. In the patients with normal neutrophil functions, vitamin C treatment neither affected neutrophil activity nor caused a clinical response. Therefore, patients suffering from recurrent furunculosis with defective neutrophil functions may be treated successfully with vitamin C, contributing to both neutrophil function recovery and a dramatic clinical response.
UR - http://www.scopus.com/inward/record.url?scp=0029822292&partnerID=8YFLogxK
U2 - 10.1093/infdis/173.6.1502
DO - 10.1093/infdis/173.6.1502
M3 - Article
C2 - 8648230
AN - SCOPUS:0029822292
SN - 0022-1899
VL - 173
SP - 1502
EP - 1505
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -