Vitamin c mitigates oxidative stress and behavioral impairments induced by deltamethrin and lead toxicity in zebrafish

Emanuela Paduraru, Elena Iuliana Flocea, Carlo C. Lazado, Ira Adeline Simionov, Mircea Nicoara, Alin Ciobica, Caterina Faggio, Roxana Jijie

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Environmental contamination from toxic metals and pesticides is an issue of great concern due to their harmful effects to human health and the ecosystems. In this framework, we assessed the adverse effects when aquatic organisms are exposed to toxicants such as deltamethrin (DM) and lead (Pb), alone or in combination, using zebrafish as a model. Moreover, we likewise evaluated the possible protective effect of vitamin C (VC) supplementation against the combined acute toxic effects of the two toxicants. Juvenile zebrafish were exposed to DM (2 μg L−1 ) and Pb (60 μg L−1 ) alone and in combination with VC (100 μg L−1 ) and responses were assessed by quantifying acetylcholin-esterase (AChE) activity, lipid peroxidation (MDA), some antioxidant enzyme activities (SOD and GPx), three‐dimension locomotion responses and changes of elements concentrations in the zebrafish body. Our results show that VC has mitigative effects against behavioral and biochemical alterations induced by a mixture of contaminants, demonstrating that it can be used as an effective antioxidant. Moreover, the observations in the study demonstrate zebrafish as a promising in vivo model for assessing the neuroprotective actions of bioactive compounds.

Original languageEnglish
Article number12714
JournalInternational Journal of Molecular Sciences
Issue number23
StatePublished - 1 Dec 2021
Externally publishedYes


  • 3D locomotion analysis
  • Deltamethrin
  • Lead
  • Protective role
  • Vitamin C
  • Zebrafish

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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