WeFold: A coopetition for protein structure prediction

George A. Khoury, Adam Liwo, Firas Khatib, Hongyi Zhou, Gaurav Chopra, Jaume Bacardit, Leandro O. Bortot, Rodrigo A. Faccioli, Xin Deng, Yi He, Pawel Krupa, Jilong Li, Magdalena A. Mozolewska, Adam K. Sieradzan, James Smadbeck, Tomasz Wirecki, Seth Cooper, Jeff Flatten, Kefan Xu, David BakerJianlin Cheng, Alexandre C.B. Delbem, Christodoulos A. Floudas, Chen Keasar, Michael Levitt, Zoran Popović, Harold A. Scheraga, Jeffrey Skolnick, Silvia N. Crivelli

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The protein structure prediction problem continues to elude scientists. Despite the introduction of many methods, only modest gains were made over the last decade for certain classes of prediction targets. To address this challenge, a social-media based worldwide collaborative effort, named WeFold, was undertaken by 13 labs. During the collaboration, the laboratories were simultaneously competing with each other. Here, we present the first attempt at "coopetition" in scientific research applied to the protein structure prediction and refinement problems. The coopetition was possible by allowing the participating labs to contribute different components of their protein structure prediction pipelines and create new hybrid pipelines that they tested during CASP10. This manuscript describes both successes and areas needing improvement as identified throughout the first WeFold experiment and discusses the efforts that are underway to advance this initiative. A footprint of all contributions and structures are publicly accessible at http://www.wefold.org.

Original languageEnglish
Pages (from-to)1850-1868
Number of pages19
JournalProteins: Structure, Function and Bioinformatics
Volume82
Issue number9
DOIs
StatePublished - 1 Jan 2014

Keywords

  • CASP
  • Coopetition
  • Foldit
  • Protein structure prediction
  • Structure refinement

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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