What is unique about superoxide toxicity as compared to other biological reductants? - a hypothesis

Gidon Czapski, Sara Goldstein, Dan Meyerstein

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Usually the toxicity of superoxide is attributed lo its ability to reduce metal ions and subsequently reoxidation of the metal by hydrogen peroxide yields deleterious oxidizing species. As many other nontoxic biological reductants reduce metal compounds, we suggest that part of the mechanism of superoxide toxicity results from its ability to oxidize metal ions bound to biological targets, which subsequently degrade the target via an intramolecular electron Transfer reaction.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalFree Radical Research
Volume4
Issue number4
DOIs
StatePublished - 1 Jan 1988

Keywords

  • Cu(III)
  • Fe(IV)
  • Haber-Weiss mechanism
  • OH
  • Superoxide

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