Whey deionization method of infant formula affects plasma lipids

Zvi Weizman, Cathy Ursacha, Shraga Shany, Drora Leader, Chaim Zegerman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Casein has proved to be hypercholesterolemic. According to results of previous studies, the casein-to-whey ratio in infant formula influences plasma lipid profile. This study explored whether different methods of whey deionization also affect levels of plasma lipids. Methods: Two types of a whey-predominant (whey 60%:casein 40%) formula which differed only in the methods used for whey deionization (ultrafiltration or electrodialysis), were fed to healthy newborn infants for 60 days, using a prospective, double-blind, randomized design. Formulas were otherwise identical in composition. Results: Groups were similar in gestational age, gender, birth weight, and growth parameters. Evaluation of fasting plasma levels after 60 days revealed significantly higher values of total cholesterol (p < 0.001) and low-density lipoprotein cholesterol (p < 0.001) in infants fed ultrafiltrated whey compared with the same values in infants fed electrodialyzed whey. Plasma levels in the two groups of very low- density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides revealed no statistically significant differences. Conclusions: Plasma lipid profile in infancy is influenced by dietary protein, not only by the casein-to-whey ratio, but also by the method of whey deionization.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number5
StatePublished - 1 Nov 1997


  • Casein
  • Cholesterol
  • Infant feeding Infant formula
  • Lipids
  • Whey


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