Whole abdominal irradiation following chemotherapy in advanced ovarian carcinoma

A. Kuten, M. Stein, M. Steiner, R. Rubinov, R. Epelbaum, Y. Cohen

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


One hundred and sixteen patients with advanced ovarian carcinoma, who underwent primary cytoreductive surgery, received 6-11 courses of chemotherapy by cis-platin (50 mg/m2) and adriamycin (50 mg/m2)every 21 days. This was followed by second lood laparotomy in 66 patients with no clinical evidence of disease. Consolidation abdominal irradiation was administered to 43 patients. Two techniques of irradiation were employed: between 1980-1983 whole abdominal irradiation was used and patients were to receive 3000 cGy in 4 weeks (Schedule I). Due to myelosuppression only 13 of 26 patients (50%) completed the planned dose of radiation. between 1983-1985 the target volume was divided into upper and lower parts. First, the lower abdomen received 3000 cGy in 3 weeks, and then the upper abdomen received the same dose (Schedule II). Sixteen of seventeen patients (94%) thus treated, completed the planned dose of radiation. The actuarial survival for all 116 patients was 28% of 5 years. Irradiated patients with negative second look laparotomy had a survival probability of 100% at 24 months. Irradiated patients with microscopic disease at second look operation had an actuarial 5-year survival of 66%. Patientsd with minimal residual disease at second look laparotomy, receiving consolidation abdominal irrdiation, had an actuarial survival of 5% only at 36 months. It is concluded that consolidation radiotherapy is effective in patients with negative or microscopic residual disease at second-look laparootomy. In regard to bone marrow tolerance split field technique of irradiation is preferred.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalInternational journal of radiation oncology, biology, physics
Issue number2
StatePublished - 1 Jan 1988
Externally publishedYes


  • Multimodality therapy
  • Ovarian carcinoma
  • Second-look laparotomy
  • Whole abdominal irradiation

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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