Why use bubble-column bioreactors?

JoséC C. Merchuk, Sigal Ben Zvi (Yona), Keshavan Niranjan

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Among the plethora of bioreactors available for aerobic culture, bubble columns, which are composed of a cylindrical vessel fitted with a gas sparger, are gaining in use. The simple construction of bubble-column reactors makes them easy to maintain. In addition, it is possible to control the degree of shear, uniformly within the reactor, which is critical to the growth of plant and animal cells in particular. This article reviews in detail the hydrodynamic, heat and mass-transfer characteristics of bubble-column bioreactors - parameters that are important for industrial scale-up.

Original languageEnglish
Pages (from-to)501-511
Number of pages11
JournalTrends in Biotechnology
Volume12
Issue number12
DOIs
StatePublished - 1 Jan 1994

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