Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans

Bashir Akhlaq Akhoon; Swapnil Pandey; Sudeep Tiwari; Rakesh Pandey

doi:10.1016/j.exger.2016.03.004

Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans

Bashir Akhlaq Akhoon, Swapnil Pandey, Sudeep Tiwari, Rakesh Pandey

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Withanolide A (steroidal lactone) forms the major constituent of the most popular herbal drug in Ayurvedic medicine, Ashwagandha. It has been used since ancient times as an alternative medicine for the treatment of a variety of age related disorders. Here we provide multiple lines of evidence indicating that Withanolide A improves healthspan, delays age-associated physiological changes and also extends the lifespan of Caenorhabditis elegans. We also report several neuroprotective benefits of this natural product, including its anti-amyloidogenic effects, alleviation of α-synuclein aggregation and neuroprotection through modulation of neural mediators like acetylcholine. We observed that Withanolide A mediates lifespan extension and promotes stress resistance via insulin/insulin-like growth factor signaling pathway. Such findings could be helpful to develop a therapeutic medicine from this natural product for the prevention or reversal of age-related ailments and to improve the survival of patients suffering from Alzheimer's or Parkinson's disease.

Original language	English
Pages (from-to)	47-56
Number of pages	10
Journal	Experimental Gerontology
Volume	78
DOIs	https://doi.org/10.1016/j.exger.2016.03.004
State	Published - 1 Jun 2016
Externally published	Yes

Keywords

Aging
Caenorhabditis elegans
Insulin/IGF-1 pathway
Neuroprotection
Withanolide A

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.exger.2016.03.004

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title = "Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans",

abstract = "Withanolide A (steroidal lactone) forms the major constituent of the most popular herbal drug in Ayurvedic medicine, Ashwagandha. It has been used since ancient times as an alternative medicine for the treatment of a variety of age related disorders. Here we provide multiple lines of evidence indicating that Withanolide A improves healthspan, delays age-associated physiological changes and also extends the lifespan of Caenorhabditis elegans. We also report several neuroprotective benefits of this natural product, including its anti-amyloidogenic effects, alleviation of α-synuclein aggregation and neuroprotection through modulation of neural mediators like acetylcholine. We observed that Withanolide A mediates lifespan extension and promotes stress resistance via insulin/insulin-like growth factor signaling pathway. Such findings could be helpful to develop a therapeutic medicine from this natural product for the prevention or reversal of age-related ailments and to improve the survival of patients suffering from Alzheimer's or Parkinson's disease.",

keywords = "Aging, Caenorhabditis elegans, Insulin/IGF-1 pathway, Neuroprotection, Withanolide A",

author = "Akhoon, {Bashir Akhlaq} and Swapnil Pandey and Sudeep Tiwari and Rakesh Pandey",

note = "Funding Information: We are grateful to the Director, CSIR–CIMAP, Lucknow, India for his kind support. BAA thanks Virendra Shukla, Shreesh Sammi and Laxmi Rathor for their useful comments and assistance in the experimental protocols. BAA also acknowledges useful discussions with Shailendra K Gupta, Shishir K Gupta and Aakansha Pant. All the strains were obtained from the Caenorhabditis Genetic Center at the University of Minnesota. BAA and ST were financially supported by CSIR India ( 31/029(0251)/2013-EMR-I and 31/34(157)/2013-EMR-I ) through SRF grants. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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doi = "10.1016/j.exger.2016.03.004",

language = "English",

volume = "78",

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journal = "Experimental Gerontology",

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AU - Akhoon, Bashir Akhlaq

AU - Pandey, Swapnil

AU - Tiwari, Sudeep

AU - Pandey, Rakesh

N1 - Funding Information: We are grateful to the Director, CSIR–CIMAP, Lucknow, India for his kind support. BAA thanks Virendra Shukla, Shreesh Sammi and Laxmi Rathor for their useful comments and assistance in the experimental protocols. BAA also acknowledges useful discussions with Shailendra K Gupta, Shishir K Gupta and Aakansha Pant. All the strains were obtained from the Caenorhabditis Genetic Center at the University of Minnesota. BAA and ST were financially supported by CSIR India ( 31/029(0251)/2013-EMR-I and 31/34(157)/2013-EMR-I ) through SRF grants. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Withanolide A (steroidal lactone) forms the major constituent of the most popular herbal drug in Ayurvedic medicine, Ashwagandha. It has been used since ancient times as an alternative medicine for the treatment of a variety of age related disorders. Here we provide multiple lines of evidence indicating that Withanolide A improves healthspan, delays age-associated physiological changes and also extends the lifespan of Caenorhabditis elegans. We also report several neuroprotective benefits of this natural product, including its anti-amyloidogenic effects, alleviation of α-synuclein aggregation and neuroprotection through modulation of neural mediators like acetylcholine. We observed that Withanolide A mediates lifespan extension and promotes stress resistance via insulin/insulin-like growth factor signaling pathway. Such findings could be helpful to develop a therapeutic medicine from this natural product for the prevention or reversal of age-related ailments and to improve the survival of patients suffering from Alzheimer's or Parkinson's disease.

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KW - Insulin/IGF-1 pathway

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ER -

Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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