TY - JOUR
T1 - Wonder or evil?
T2 - Multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals
AU - Datta, Shivika
AU - Ramamurthy, Praveen C.
AU - Anand, Uttpal
AU - Singh, Simranjeet
AU - Singh, Amritpal
AU - Dhanjal, Daljeet Singh
AU - Dhaka, Vaishali
AU - Kumar, Sanjay
AU - Kapoor, Dhriti
AU - Nandy, Samapika
AU - Kumar, Manoj
AU - Koshy, Eapen P.
AU - Dey, Abhijit
AU - Proćków, Jarosław
AU - Singh, Joginder
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Cannabis sativa, widely known as ‘Marijuana’ poses a dilemma for being a blend of both good and bad medicinal effects. The historical use of Cannabis for both medicinal and recreational purposes suggests it to be a friendly plant. However, whether the misuse of Cannabis and the cannabinoids derived from it can hamper normal body physiology is a focus of ongoing research. On the one hand, there is enough evidence to suggest that misuse of marijuana can cause deleterious effects on various organs like the lungs, immune system, cardiovascular system, etc. and also influence fertility and cause teratogenic effects. However, on the other hand, marijuana has been found to offer a magical cure for anorexia, chronic pain, muscle spasticity, nausea, and disturbed sleep. Indeed, most recently, the United Nations has given its verdict in favour of Cannabis declaring it as a non-dangerous narcotic. This review provides insights into the various health effects of Cannabis and its specialized metabolites and indicates how wise steps can be taken to promote good use and prevent misuse of the metabolites derived from this plant.
AB - Cannabis sativa, widely known as ‘Marijuana’ poses a dilemma for being a blend of both good and bad medicinal effects. The historical use of Cannabis for both medicinal and recreational purposes suggests it to be a friendly plant. However, whether the misuse of Cannabis and the cannabinoids derived from it can hamper normal body physiology is a focus of ongoing research. On the one hand, there is enough evidence to suggest that misuse of marijuana can cause deleterious effects on various organs like the lungs, immune system, cardiovascular system, etc. and also influence fertility and cause teratogenic effects. However, on the other hand, marijuana has been found to offer a magical cure for anorexia, chronic pain, muscle spasticity, nausea, and disturbed sleep. Indeed, most recently, the United Nations has given its verdict in favour of Cannabis declaring it as a non-dangerous narcotic. This review provides insights into the various health effects of Cannabis and its specialized metabolites and indicates how wise steps can be taken to promote good use and prevent misuse of the metabolites derived from this plant.
KW - Cannabinoids
KW - Cannabis sativa
KW - Chemical components
KW - Medical marijuana
KW - Phytochemicals
KW - Psychoactive
KW - Tetrahydrocannabinol
KW - Therapeutic roles
UR - http://www.scopus.com/inward/record.url?scp=85113828706&partnerID=8YFLogxK
U2 - 10.1016/j.sjbs.2021.08.036
DO - 10.1016/j.sjbs.2021.08.036
M3 - Review article
C2 - 34867033
AN - SCOPUS:85113828706
SN - 1319-562X
VL - 28
SP - 7290
EP - 7313
JO - Saudi Journal of Biological Sciences
JF - Saudi Journal of Biological Sciences
IS - 12
ER -