@article{af9595edede740d0ac09fa8eaa25666b,
title = "WONOEP appraisal: Imaging biomarkers in epilepsy",
abstract = "Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood–brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organized in 2015 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). Here we present an extended summary of the discussed issues and provide an overview of the current state of knowledge regarding the biomarker potential of different neuroimaging approaches for epilepsy.",
keywords = "Biomarker, Blood–brain barrier, Epileptogenesis, Imaging, Inflammation, Traumatic brain injury",
author = "{van Vliet}, {Erwin A.} and Stefanie Dedeurwaerdere and Cole, {Andrew J.} and Alon Friedman and Koepp, {Matthias J.} and Heidrun Potschka and Riikka Immonen and Asla Pitk{\"a}nen and Paolo Federico",
note = "Funding Information: This review is devised as extended account of the discussion that took place during the XIII WONOEP (Heybeliada Island, Istanbul, Turkey, August 31– to September 4, 2015) organized and supported by the Neurobiology Commission of the International League Against Epilepsy and generously sponsored by Harinarayan Family Foundation (U.S.A.) Cyberonics Inc.(U.S.A.), Insys Therapeutics Inc. (U.S.A.), Astellas Pharma (Japan), MSD (Japan), and Meiji Seika Pharma (Japan). We thank Prof. Jeroen Verhaeghe (Molecular Imaging Center Antwerp) for providing the rat FDG- and TSPO-PET scan images for Figure. Dr. Van Vliet is supported by the European Union's Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 602102 (EPITARGET) and by the Dutch Epilepsy Foundation, project number 16-05. Dr. Dedeurwaerdere is supported by BOF UAntwerpen; The Research Foundation Flanders (FWO) (grant numbers 1.5.110.14N, G.038515N, and G.A009.13N); the Queen Elisabeth Medical Foundation for Neurosciences; and the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642881. Dr. H. Potschka is supported by Deutsche Forschungsgemeinschaft PO681/8-1. Dr. Pitk{\"a}nen is supported by the European Union's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 602102 (EPITARGET) and by Academy of Finland. Dr. Immonen is supported by Academy of Finland. Dr. Federico is supported by Canadian Institutes of Health Research (MOP-136839). Publisher Copyright: Wiley Periodicals, Inc. {\textcopyright} 2016 International League Against Epilepsy",
year = "2017",
month = mar,
day = "1",
doi = "10.1111/epi.13621",
language = "English",
volume = "58",
pages = "315--330",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",
}