Wound healing and longevity: Lessons from long-lived αMUPA mice

Hagai Yanai, Dimitri Toren, Klemens Vierlinger, Manuela Hofner, Christa Nöhammer, Marco Chilosi, Arie Budovsky, Vadim E. Fraifeld

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Does the longevity phenotype offer an advantage in wound healing (WH)? In an attempt to answer this question, we explored skin wound healing in the long-lived transgenic αMUPA mice, a unique model of genetically extended life span. These mice spontaneously eat less, preserve their body mass, are more resistant to spontaneous and induced tumorigenesis and live longer, thus greatly mimicking the effects of caloric restriction (CR). We found that αMUPA mice showed a much slower age-related decline in the rate of WH than their wild-type counterparts (FVB/N). After full closure of the wound, gene expression in the skin of old αMUPA mice returned close to basal levels. In contrast, old FVB/N mice still exhibited significant upregulation of genes associated with growth-promoting pathways, apoptosis and cellcell/ cell-extra cellular matrix interaction, indicating an ongoing tissue remodeling or an inability to properly shut down the repair process. It appears that the CR-like longevity phenotype is associated with more balanced and efficient WH mechanisms in old age, which could ensure a long-term survival advantage.

Original languageEnglish
Pages (from-to)167-176
Number of pages10
JournalAging
Volume7
Issue number3
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Aging
  • Caloric restriction
  • Gene expression
  • Growth-promoting pathways
  • Wound healing
  • αMUPA mice

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