X-ray microanalysis of uremic nephrocalcinosis

M. S. Goligorsky; C. Chaimovitz; J. Rapoport; L. Zevin; A. Kiryati; S. Lach

doi:10.1159/000183053

X-ray microanalysis of uremic nephrocalcinosis

M. S. Goligorsky, C. Chaimovitz, J. Rapoport, L. Zevin, A. Kiryati, S. Lach

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The nature of uremic nephrocalcinosis was studied by means of X-ray microanalysis in 5/6 nephrectomized rats. The data show that calcified deposits in the renal parenchyma of uremic rats contained substantial amounts of calcium, magnesium, aluminum and silicon. Since calcificates did not reveal a uniform composition they were arbitrarily divided into 3 categories: 'high-calcium' with Mg:Al:Si:Ca molar ratios 7:3:8:37; 'low-calcium' particles were characterized by Fe:Mg:Al:Ca:Si molar ratios 7:3:5:6:13; while 'intermediate-calcium' particles showed Al:Mg:Si:Ca molar ratios equivalent to 2:4:6:7. The variability of calcified deposits in the renal parenchyma of 5/6 nephrectomized rats might be due to different sources, different environmental conditions along the nephron and different stages of calcification process. It is suggested that aluminum and silicon content of deposits may be of value in further characterization of uremic nephrocalcinosis.

Original language	English
Pages (from-to)	89-93
Number of pages	5
Journal	Nephron
Volume	35
Issue number	2
DOIs	https://doi.org/10.1159/000183053
State	Published - 1 Jan 1983
Externally published	Yes

ASJC Scopus subject areas

Physiology
Nephrology
Physiology (medical)
Urology

Access to Document

10.1159/000183053

Cite this

@article{447eb6e9b7d74eff88ee9b477881c631,

title = "X-ray microanalysis of uremic nephrocalcinosis",

abstract = "The nature of uremic nephrocalcinosis was studied by means of X-ray microanalysis in 5/6 nephrectomized rats. The data show that calcified deposits in the renal parenchyma of uremic rats contained substantial amounts of calcium, magnesium, aluminum and silicon. Since calcificates did not reveal a uniform composition they were arbitrarily divided into 3 categories: 'high-calcium' with Mg:Al:Si:Ca molar ratios 7:3:8:37; 'low-calcium' particles were characterized by Fe:Mg:Al:Ca:Si molar ratios 7:3:5:6:13; while 'intermediate-calcium' particles showed Al:Mg:Si:Ca molar ratios equivalent to 2:4:6:7. The variability of calcified deposits in the renal parenchyma of 5/6 nephrectomized rats might be due to different sources, different environmental conditions along the nephron and different stages of calcification process. It is suggested that aluminum and silicon content of deposits may be of value in further characterization of uremic nephrocalcinosis.",

author = "Goligorsky, {M. S.} and C. Chaimovitz and J. Rapoport and L. Zevin and A. Kiryati and S. Lach",

year = "1983",

month = jan,

day = "1",

doi = "10.1159/000183053",

language = "English",

volume = "35",

pages = "89--93",

journal = "Nephron",

issn = "0028-2766",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - X-ray microanalysis of uremic nephrocalcinosis

AU - Goligorsky, M. S.

AU - Chaimovitz, C.

AU - Rapoport, J.

AU - Zevin, L.

AU - Kiryati, A.

AU - Lach, S.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The nature of uremic nephrocalcinosis was studied by means of X-ray microanalysis in 5/6 nephrectomized rats. The data show that calcified deposits in the renal parenchyma of uremic rats contained substantial amounts of calcium, magnesium, aluminum and silicon. Since calcificates did not reveal a uniform composition they were arbitrarily divided into 3 categories: 'high-calcium' with Mg:Al:Si:Ca molar ratios 7:3:8:37; 'low-calcium' particles were characterized by Fe:Mg:Al:Ca:Si molar ratios 7:3:5:6:13; while 'intermediate-calcium' particles showed Al:Mg:Si:Ca molar ratios equivalent to 2:4:6:7. The variability of calcified deposits in the renal parenchyma of 5/6 nephrectomized rats might be due to different sources, different environmental conditions along the nephron and different stages of calcification process. It is suggested that aluminum and silicon content of deposits may be of value in further characterization of uremic nephrocalcinosis.

AB - The nature of uremic nephrocalcinosis was studied by means of X-ray microanalysis in 5/6 nephrectomized rats. The data show that calcified deposits in the renal parenchyma of uremic rats contained substantial amounts of calcium, magnesium, aluminum and silicon. Since calcificates did not reveal a uniform composition they were arbitrarily divided into 3 categories: 'high-calcium' with Mg:Al:Si:Ca molar ratios 7:3:8:37; 'low-calcium' particles were characterized by Fe:Mg:Al:Ca:Si molar ratios 7:3:5:6:13; while 'intermediate-calcium' particles showed Al:Mg:Si:Ca molar ratios equivalent to 2:4:6:7. The variability of calcified deposits in the renal parenchyma of 5/6 nephrectomized rats might be due to different sources, different environmental conditions along the nephron and different stages of calcification process. It is suggested that aluminum and silicon content of deposits may be of value in further characterization of uremic nephrocalcinosis.

UR - http://www.scopus.com/inward/record.url?scp=0020606047&partnerID=8YFLogxK

U2 - 10.1159/000183053

DO - 10.1159/000183053

M3 - Article

C2 - 6621760

AN - SCOPUS:0020606047

SN - 0028-2766

VL - 35

SP - 89

EP - 93

JO - Nephron

JF - Nephron

IS - 2

ER -

X-ray microanalysis of uremic nephrocalcinosis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this