Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

C. Stremmel; R. Schuchert; F. Wagner; R. Thaler; T. Weinberger; R. Pick; E. Mass; H. C. Ishikawa-Ankerhold; A. Margraf; S. Hutter; R. Vagnozzi; S. Klapproth; J. Frampton; S. Yona; C. Scheiermann; J. D. Molkentin; U. Jeschke; M. Moser; M. Sperandio; S. Massberg; F. Geissmann; C. Schulz

doi:10.1038/s41467-017-02492-2

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

C. Stremmel, R. Schuchert, F. Wagner, R. Thaler, T. Weinberger, R. Pick, E. Mass, H. C. Ishikawa-Ankerhold, A. Margraf, S. Hutter, R. Vagnozzi, S. Klapproth, J. Frampton, S. Yona, C. Scheiermann, J. D. Molkentin, U. Jeschke, M. Moser, M. Sperandio, S. MassbergF. Geissmann, C. Schulz

Research output: Contribution to journal › Article › peer-review

182 Scopus citations

Abstract

Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.

Original language	English GB
Article number	75
Pages (from-to)	75
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-017-02492-2
State	Published - 1 Jan 2018
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-017-02492-2

http://adsabs.harvard.edu/abs/2018NatCo...9...75S

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Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., Mass, E., Ishikawa-Ankerhold, H. C., Margraf, A., Hutter, S., Vagnozzi, R., Klapproth, S., Frampton, J., Yona, S., Scheiermann, C., Molkentin, J. D., Jeschke, U., Moser, M., Sperandio, M., ... Schulz, C. (2018). Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nature Communications, 9(1), 75. Article 75. https://doi.org/10.1038/s41467-017-02492-2

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title = "Yolk sac macrophage progenitors traffic to the embryo during defined stages of development",

abstract = "Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.",

author = "C. Stremmel and R. Schuchert and F. Wagner and R. Thaler and T. Weinberger and R. Pick and E. Mass and Ishikawa-Ankerhold, {H. C.} and A. Margraf and S. Hutter and R. Vagnozzi and S. Klapproth and J. Frampton and S. Yona and C. Scheiermann and Molkentin, {J. D.} and U. Jeschke and M. Moser and M. Sperandio and S. Massberg and F. Geissmann and C. Schulz",

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Stremmel, C, Schuchert, R, Wagner, F, Thaler, R, Weinberger, T, Pick, R, Mass, E, Ishikawa-Ankerhold, HC, Margraf, A, Hutter, S, Vagnozzi, R, Klapproth, S, Frampton, J, Yona, S, Scheiermann, C, Molkentin, JD, Jeschke, U, Moser, M, Sperandio, M, Massberg, S, Geissmann, F & Schulz, C 2018, 'Yolk sac macrophage progenitors traffic to the embryo during defined stages of development', Nature Communications, vol. 9, no. 1, 75, pp. 75. https://doi.org/10.1038/s41467-017-02492-2

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T1 - Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

AU - Stremmel, C.

AU - Schuchert, R.

AU - Wagner, F.

AU - Thaler, R.

AU - Weinberger, T.

AU - Pick, R.

AU - Mass, E.

AU - Ishikawa-Ankerhold, H. C.

AU - Margraf, A.

AU - Hutter, S.

AU - Vagnozzi, R.

AU - Klapproth, S.

AU - Frampton, J.

AU - Yona, S.

AU - Scheiermann, C.

AU - Molkentin, J. D.

AU - Jeschke, U.

AU - Moser, M.

AU - Sperandio, M.

AU - Massberg, S.

AU - Geissmann, F.

AU - Schulz, C.

PY - 2018/1/1

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N2 - Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.

AB - Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.

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SN - 2041-1723

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SP - 75

JO - Nature Communications

JF - Nature Communications

IS - 1

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ER -

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Abstract

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