Young adult-born neurons improve odor coding by mitral cells

H. Shani-Narkiss; A. Vinograd; I. D. Landau; G. Tasaka; N. Yayon; S. Terletsky; M. Groysman; I. Maor; H. Sompolinsky; A. Mizrahi

doi:10.1038/s41467-020-19472-8

Young adult-born neurons improve odor coding by mitral cells

H. Shani-Narkiss, A. Vinograd, I. D. Landau, G. Tasaka, N. Yayon, S. Terletsky, M. Groysman, I. Maor, H. Sompolinsky, A. Mizrahi

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

New neurons are continuously generated in the adult brain through a process called adult neurogenesis. This form of plasticity has been correlated with numerous behavioral and cognitive phenomena, but it remains unclear if and how adult-born neurons (abNs) contribute to mature neural circuits. We established a highly specific and efficient experimental system to target abNs for causal manipulations. Using this system with chemogenetics and imaging, we found that abNs effectively sharpen mitral cells (MCs) tuning and improve their power to discriminate among odors. The effects on MCs responses peaked when abNs were young and decreased as they matured. To explain the mechanism of our observations, we simulated the olfactory bulb circuit by modelling the incorporation of abNs into the circuit. We show that higher excitability and broad input connectivity, two well-characterized features of young neurons, underlie their unique ability to boost circuit computation.

Original language	English
Article number	5867
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19472-8
State	Published - 1 Dec 2020
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-020-19472-8

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abstract = "New neurons are continuously generated in the adult brain through a process called adult neurogenesis. This form of plasticity has been correlated with numerous behavioral and cognitive phenomena, but it remains unclear if and how adult-born neurons (abNs) contribute to mature neural circuits. We established a highly specific and efficient experimental system to target abNs for causal manipulations. Using this system with chemogenetics and imaging, we found that abNs effectively sharpen mitral cells (MCs) tuning and improve their power to discriminate among odors. The effects on MCs responses peaked when abNs were young and decreased as they matured. To explain the mechanism of our observations, we simulated the olfactory bulb circuit by modelling the incorporation of abNs into the circuit. We show that higher excitability and broad input connectivity, two well-characterized features of young neurons, underlie their unique ability to boost circuit computation.",

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AU - Vinograd, A.

AU - Landau, I. D.

AU - Tasaka, G.

AU - Yayon, N.

AU - Terletsky, S.

AU - Groysman, M.

AU - Maor, I.

AU - Sompolinsky, H.

AU - Mizrahi, A.

PY - 2020/12/1

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AB - New neurons are continuously generated in the adult brain through a process called adult neurogenesis. This form of plasticity has been correlated with numerous behavioral and cognitive phenomena, but it remains unclear if and how adult-born neurons (abNs) contribute to mature neural circuits. We established a highly specific and efficient experimental system to target abNs for causal manipulations. Using this system with chemogenetics and imaging, we found that abNs effectively sharpen mitral cells (MCs) tuning and improve their power to discriminate among odors. The effects on MCs responses peaked when abNs were young and decreased as they matured. To explain the mechanism of our observations, we simulated the olfactory bulb circuit by modelling the incorporation of abNs into the circuit. We show that higher excitability and broad input connectivity, two well-characterized features of young neurons, underlie their unique ability to boost circuit computation.

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Young adult-born neurons improve odor coding by mitral cells

Abstract

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