Zinc homeostasis and brain injury

Stefano Sensi, Erica Rockabrand, Israel Sekler

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Cumulating evidence suggest that Zn2+ dys/homeostasis can play a major role in promoting brain injury in excitotoxic syndromes. Zn2+ homeostasis in the brain is regulated through highly dynamic pathways and is deeply connected with other major signaling pathways, such as NO- and MAP kinase-dependent systems. Zn2+ signaling in neurons and glia also interplays with proton and Ca2+ homeostasis. Zn2+ appears to promote injury with greater potency compared to Ca2+ and as such the cation may be an underappreciated mediator of excitotoxicity, which for many years has been described mainly as a Ca2+- dependent phenomenon.

Original languageEnglish
Title of host publicationInteraction Between Neurons and Glia in Aging and Disease
PublisherSpringer US
Number of pages24
ISBN (Print)9780387708294
StatePublished - 1 Dec 2007

ASJC Scopus subject areas

  • General Neuroscience


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