Zinc in the physiology and pathology of the CNS

Stefano L. Sensi, Pierre Paoletti, Ashley I. Bush, Israel Sekler

Research output: Contribution to journalReview articlepeer-review

515 Scopus citations

Abstract

The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology. The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial intra-and intercellular signalling ion of the CNS, and hence of the neurophysiological importance of zinc-dependent pathways and the injurious effects of zinc dyshomeostasis. The development of some innovative therapeutic strategies is aimed at controlling and preventing the damaging effects of this cation in neurological conditions such as stroke and Alzheimer's disease.

Original languageEnglish
Pages (from-to)780-791
Number of pages12
JournalNature Reviews Neuroscience
Volume10
Issue number11
DOIs
StatePublished - 1 Nov 2009

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