Abstract
Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn2+, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn2+-homeostatic proteins that are responsible for maintaining Zn2+ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn2+ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn2+-homeostatic proteins.
Original language | English |
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Title of host publication | Zinc Signaling |
Publisher | Springer Singapore |
Pages | 347-363 |
Number of pages | 17 |
ISBN (Electronic) | 9789811505577 |
ISBN (Print) | 9789811505560 |
DOIs | |
State | Published - 1 Jan 2020 |
Keywords
- Barrier function
- Intestine
- Slc30a
- Slc39a
- Zinc
- Zinc absorption
- Zip
- Znr/gpr39
- Znt
ASJC Scopus subject areas
- Medicine (all)
- Biochemistry, Genetics and Molecular Biology (all)