Zinc signaling (zinc’ing) in intestinal function

Michal Hershfinkel; Johnny Iv; Shannon L. Kelleher

doi:10.1007/978-981-15-0557-7_17

Zinc signaling (zinc’ing) in intestinal function

Michal Hershfinkel, Johnny Iv, Shannon L. Kelleher

Department of Physiology and Cell Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn²⁺, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn²⁺-homeostatic proteins that are responsible for maintaining Zn²⁺ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn²⁺ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn²⁺-homeostatic proteins.

Original language	English
Title of host publication	Zinc Signaling
Publisher	Springer Singapore
Pages	347-363
Number of pages	17
ISBN (Electronic)	9789811505577
ISBN (Print)	9789811505560
DOIs	https://doi.org/10.1007/978-981-15-0557-7_17
State	Published - 1 Jan 2020

Keywords

Barrier function
Intestine
Slc30a
Slc39a
Zinc
Zinc absorption
Zip
Znr/gpr39
Znt

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-981-15-0557-7_17

Cite this

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abstract = "Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn2+, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn2+-homeostatic proteins that are responsible for maintaining Zn2+ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn2+ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn2+-homeostatic proteins.",

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AU - Iv, Johnny

AU - Kelleher, Shannon L.

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KW - Slc39a

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Zinc signaling (zinc’ing) in intestinal function

Abstract

Keywords

ASJC Scopus subject areas

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