Zinc Signaling (Zinc’ing) in Intestinal Function

Michal Hershfinkel; Johnny Iv; Shannon L. Kelleher

doi:10.1007/978-981-15-0557-7_17

Zinc Signaling (Zinc’ing) in Intestinal Function

Michal Hershfinkel
, Johnny Iv
, Shannon L. Kelleher

Department of Physiology and Cell Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn²⁺+, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn²⁺+-homeostatic proteins that are responsible for maintaining Zn²⁺+ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn²⁺+ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn²⁺+-homeostatic proteins.

Original language	English
Title of host publication	Zinc Signaling
Subtitle of host publication	Second Edition
Publisher	Springer Nature
Pages	347-363
Number of pages	17
ISBN (Electronic)	9789811505577
ISBN (Print)	9789811505560
DOIs	https://doi.org/10.1007/978-981-15-0557-7_17
State	Published - 1 Jan 2019

Keywords

Barrier function
Intestine
SLC30A
SLC39A
Zinc
Zinc absorption
ZIP
ZnR/GPR39
ZnT

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-981-15-0557-7_17

Cite this

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abstract = "Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn2++, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn2++-homeostatic proteins that are responsible for maintaining Zn2++ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn2++ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn2++-homeostatic proteins.",

keywords = "Barrier function, Intestine, SLC30A, SLC39A, Zinc, Zinc absorption, ZIP, ZnR/GPR39, ZnT",

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AU - Hershfinkel, Michal

AU - Iv, Johnny

AU - Kelleher, Shannon L.

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PY - 2019/1/1

Y1 - 2019/1/1

N2 - Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn2++, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn2++-homeostatic proteins that are responsible for maintaining Zn2++ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn2++ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn2++-homeostatic proteins.

AB - Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn2++, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn2++-homeostatic proteins that are responsible for maintaining Zn2++ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn2++ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn2++-homeostatic proteins.

KW - Barrier function

KW - Intestine

KW - SLC30A

KW - SLC39A

KW - Zinc

KW - Zinc absorption

KW - ZIP

KW - ZnR/GPR39

KW - ZnT

UR - https://www.scopus.com/pages/publications/105045100906

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DO - 10.1007/978-981-15-0557-7_17

M3 - Chapter

AN - SCOPUS:105045100906

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SP - 347

EP - 363

BT - Zinc Signaling

PB - Springer Nature

ER -

Zinc Signaling (Zinc’ing) in Intestinal Function

Abstract

Keywords

ASJC Scopus subject areas

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