Zn2+, a dynamic signaling molecule

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    7 Scopus citations

    Abstract

    Zinc is essential for cell proliferation thereby promoting growth and development, yet a rise of intracellular zinc is a leading cause of neuronal cell death in excitotoxic syndromes. While pervious studies have addressed mostly the structural role of zinc as a cofactor of numerous enzymes and zinc finger proteins, recent data suggest that zinc is acting as a signaling molecule. Despite the accumulating knowledge on the transporters, which are shown to maintain cellular and sub-cellular zinc homeostasis, the mechanisms by which they function are much less understood. Changes in extracellular or intracellular zinc trigger the activation of major signaling pathways, partially mediated by a specific zinc sensing receptor, which are linked to either cell growth or cell death. These proteins, which are regulated by zinc, will be the subject of this review. The major challenges in future studies will be to reveal the cellular network of zinc signaling and their links to cellular zinc homeostasis.

    Original languageEnglish
    Title of host publicationMolecular Biology of Metal Homeostasis and Detoxification
    Subtitle of host publicationFrom Microbes to Man
    EditorsMarkus J. Tamas, Enrico Martinoia
    Place of PublicationGermany
    PublisherSpringer-Verlag Berlin Heidelberg
    Pages131-153
    Number of pages23
    ISBN (Electronic)3-540-22175-1
    ISBN (Print)978-3-540-22175-3
    DOIs
    StatePublished - 2005

    Publication series

    NameTopics in Current Genetics
    Volume14
    ISSN (Print)1610-2096
    ISSN (Electronic)1610-6970

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Developmental Biology
    • Cell Biology

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